224 EXPRESSION PROFILE OF CARBONIC ANHYDRASES IN ARTICULAR CARTILAGE
نویسندگان
چکیده
منابع مشابه
Structure and expression of mammalian carbonic anhydrases.
tions make it possible to ascribe specific roles to particular residues, such as the conserved glycine residues 141 at bends in the basic fold which appear to constitute alcohol dchydrogenase per se. Each of these concepts can now be further tested by directed mutagenesis. Regarding the enzymic mechanisms, the basic properties of the zinc dehydrogenases have essentially been known for some time...
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Sequence studies of human erythrocyte carbonic anhydrase B show that it contains 256 residues. A series of relatively small peptides soluble in aqueous solutions obtained by chymotryptic and tryptic digestion of the enzyme, large peptides containing only COOH-terminal lysine or arginine as well as those resulting from more limited cleavage of the enzyme, and cyanogen bromide cleavage products s...
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THE CONCEPT OF THE TRANSPORT METABOLON A metabolon has been defined as a “temporary, structural-functional, supramolecular complex of sequential metabolic enzymes and cellular structural elements, in which metabolites are passed from one active site to another without complete equilibration with the bulk cellular fluids” (Srere, 1985, 1987). This substrate channeling should decrease transit tim...
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The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important mediator of gene expression patterns in tumors, although the range of responding genes is still incompletely defined. Here we show that the tumor-associated carbonic anhydrases (CAs) are tightly regulated by this system. Both CA9 and CA12 were strongly induced by hypoxia in a range of tumor cell lines. In...
متن کاملPolyamines and α-Carbonic Anhydrases.
Natural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes. Recent examples of this type include the discovery of the coumarins and the polyamine natural products as atypical chemotypes for the inhibition of the metalloenzymes carbonic anhydrases (CAs; EC 4.2.2.1). CA enzymes are establish...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2011
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(11)60251-3